Oxlade-Chamberlain has been struggling with a groin injury, while Rosicky has a thigh concern, and Gibbs will have an ankle problem assessed.
Midfielder Mathieu Flamini is suspended, so fit-again Wales midfielder Aaron Ramsey is expected to start and as in previous rounds Lukas Fabianski will play in goal ahead of regular number one Wojciech Szczesny.
Centre-half Laurent Koscielny (calf), midfielder Serge Gnabry (knee), Germany international Mesut Ozil (hamstring), England midfielder Jack Wilshere (foot) are all still recovering, as are Abou Diaby and Theo Walcott (both knee).
Wigan manager Uwe Rosler faces a decision over who to select as his goalkeeper.
Scott Carson was recalled in the midweek loss to Millwall and started in the quarter-final win over Manchester City, but is not certain of getting the nod ahead of Rosler's usual first choice, Ali Al Habsi.
The Latics manager remains without Ben Watson (broken leg), Chris McCann (knee) and Roger Espinoza (hernia), while Rob Kiernan and Martyn Waghorn are both cup-tied. However, loanees Nicky Maynard, Josh McEachran, Nick Powell and Jack Collison are all eligible for the holders.
Rosler rested James Perch on Tuesday - another yellow card for him would have triggered a suspension, and the full-back, along with the likes of Callum McManaman and Jordi Gomez, are likely to come back in.