Mame Biram Diouf, who joined Stoke on a free transfer from Hannover, played the first 45 minutes for Mark Hughes' side in Rottach-Egern before Phil Bardsley, Steve Sidwell and Dionatan Teixeira - a Brazilian-born Slovakia defender - turned out for the second half.
Diouf and right-back Andy Wilkinson went close to opening the scoring for Stoke, but it was Monchengladbach that went ahead shortly after half-time when Thorgan Hazard, brother of Chelsea's Eden and on loan from the Blues for the season, took advantage of a misplaced Charlie Adam pass.
Stoke ensured they would not get pre-season off to a losing start, however, when Peter Crouch tapped into an empty net following a powerful run from Jon Walters.
Asmir Begovic, Geoff Cameron and Peter Odemwingie all sat out of the game having been granted extended leave following the World Cup, while neither Wilson Palacios, who also featured in Brazil, nor Cameron Jerome travelled with the squad to Germany as they close on moves away from the club.
Stoke XI, first half: Butland, Wilkinson, Shawcross, Wilson, Muniesa, Shotton, Ness, Ireland, N'Zonzi, Arnautovic, Diouf.
Stoke XI, second half: Sorensen, Bardsley, Huth, Teixeira, Pieters, Walters, Sidwell, Whelan, Adam, Shea, Crouch.