Vazquez was unable to score a single goal during his loan spell in the Premier League but decided the game in just his second appearance since returning to Getafe, bundling the ball home from a couple of yards out.
Cosmin Contra's side were just about worthy winners, although goalkeeper Vicente Guaita was forced to make two top quality saves to prevent an equaliser.
Both sides went into the game desperate for points, Getafe having been well beaten at Celta Vigo last week, while Almeria were left cursing their luck after conceding a 94th minute equaliser to Espanyol.
The hosts made the better start to the game and deserved to take the lead just before the half-hour mark. Colombian winger Fredy Hinestroza broke down the left-wing after capitalising on a misplaced ball by an Almeria defender and sent in a deep cross to the near post, where Vazquez was waiting to convert with his chest.
Guaita made the first of his two vital interventions a minute before half-time, clawing away a near post shot from Jonathan Zongo from a corner.
The former Valencia stopper came to his new side's rescue again 10 minutes into the second half, diving low to keep out a close range effort from Almeria striker Tomer Hemed.
The game was delayed later in the second half when Hinestroza had to be substituted with an apparent shoulder injury, the Colombian writhing in pain as he left the pitch.
Pablo Sarabia could have killed off the game with eight minutes remaining when a deflected cross dropped for him near the far post, but the Spain under-21 international volleyed high over the bar, and then earned himself a booking for arguing that he should have been awarded a penalty for a clash with Almeria defender Ximo Navarro.
A few minutes later Almeria's Thai striker Teerasil Dangda had an opportunity to level when the ball sat up for him on the edge of the area following a failed Getafe clearance, but the 26-year old could not get enough power on his header and the ball sailed wide.