Trailing 2-0 after the first leg of the third qualifying round, manager Stuart McCall has decided not to risk the experienced trio given the short turnaround time before their Scottish Premiership clash against Aberdeen at Fir Park on Sunday.
Motherwell will return from their trip at around 3am on Friday - via a tarmac stop in Poland to circumvent bureaucracy over entering Russia on a foreign plane.
And McCall feels there is no point risking over-working three key players at this stage of the season.
"If we had been down in France, I would think different," McCall said.
"It's the travelling, and the six and a half hours on the plane after the game, that comes into my thoughts.
"There are two or three lads who are not carrying injuries but are prone to stiffen up with backs and hamstrings, so it's for those reasons.
"They will stay back and train for a couple of days and be fresh for Sunday."
McFadden has still not played 90 minutes this season after starting pre-season training a week after his team-mates and going off in a friendly at Cowdenbeath with a tight hamstring.
McCall added: "Would I have taken them all if we had been at 0-0? Possibly.
"If the result had been slightly different I might have taken them, but having spoken to our physio, and with the six-and-a-half-hour journey after the game, and the short recovery time, it certainly does come into the thinking, and I want them all available for Sunday."
However, McCall would not concede that the tie was over despite his selection decision.
"We are keeping the experienced back four intact and hopefully we can get a solid platform, and who knows? If we can get the first goal it puts a different perspective on the tie."