Eden Hazard was the star of the show for Chelsea as he netted a hat-trick to condemn Newcastle to a second successive 3-0 defeat in a week.
But it could have been different had Sissoko converted Newcastle's best goalscoring opportunity at 1-0 down and his failure to find the net was compounded by Chelsea scoring their second goal almost immediately after Petr Cech's save from the Newcastle midfielder.
"For part of the first half I thought we played very well and we had a fantastic chance at 1-0 but unfortunately we missed it and then they went down the other end and scored again," said Pardew.
"There were a few positives. Sammy Ameobi did well and Luuk de Jong gave the type of performance that in the next 13 games I think will be important for us."
Pardew was disappointed with defender Mapou Yanga-Mbiwa after his needless foul on Samuel Eto'o gifted Chelsea a penalty from which Hazard scored his third goal of the game.
"I'm a little bit disappointed. I don't know why he's grabbed him like that. It was a really soft goal," added Pardew.
The Magpies boss admitted his side struggled to contain the in-form Hazard, describing the Belgian's performance as "excellent."
"He's at the top of his game. His work rate and everything about him today was excellent."