Alan Pardew’s men started off last season by facing Manuel Pellegrini’s side, but will hope to improve upon a 4-0 defeat at the Etihad Stadium.
A trip to Aston Villa and the visit of Crystal Palace concludes the opening month of the season, while September starts with a trek to Pardew’s former club Southampton.
The opening derby of the season comes the weekend before Christmas when Sunderland visit St James’ Park on December 20, while Boxing Day will see Newcastle head to Manchester United.
Newcastle are at home to Everton two days later and then have another home game to start the New Year when promoted Burnley visit the north east.
The return derby at the Stadium of Light is scheduled for April 4 before Newcastle round off the season at home to former manager Sam Allardyce’s West Ham United side on May 24.
Opening three games:
August 16 - Manchester City (h)
August 23 - Aston Villa (a)
August 30 - Crystal Palace (h)