Goalkeeper David De Gea, defender Rio Ferdinand. midfielder Michael Carrick and forward Robin van Persie were all selected by their peers as the best players in their positions.
Dutchman van Persie, who moved to Old Trafford from Arsenal last summer, has scored 25 goals so far this term to help United win their 20th league title.
Chelsea had midfielders Eden Hazard and Juan Mata chosen, and Tottenham Hotspur central defender Jan Vertonghen and Gareth Bale were both included in the 11.
Manchester City's dependable full-back Pablo Zabaleta, Leighton Baines of Everton and, controversial forward Luis Suarez, of Liverpool, made up the stellar line-up.
Zabaleta tweeted from @pablo_zabaleta: "Truly humbled to be included within the @PFA Team Of The Year. It's an honour to play and be named alongside such great players. Thanks."
PFA's 2012/13 team of year: De Gea (Manchester United), Zabaleta (Manchester City), Ferdinand (Manchester United), Vertonghen (Tottenham Hotspur), Baines (Everton), Hazard (Chelsea), Carrick (Manchester United), Mata (Chelsea), Bale (Tottenham Hotspur), Suarez (Liverpool), Van Persie (Manchester United)