The France defender, who was signed from Lille during the transfer window, misses out with Newcastle opting to name Moussa Sissoko, Mapou Yanga-Mbiwa and Massadio Haidara as their three additions for the remainder of the competition.
Debuchy is eligible as former club Lille are no longer involved in Europe but each club is only allowed to make three changes and Alan Pardew has opted not to include him ahead of their clash with FC Metalist Kharkiv.
Tottenham have added new signing Lewis Holtby to their squad for the latter stages - starting with their round 32 game against Lyon - following his January arrival from Schalke.
Liverpool, who play Zenit St Petersburg, are unable to call upon new signing Philippe Coutinho, who arrived from Inter Milan, or fellow January signing Daniel Sturridge following his move from Chelsea.
Similarly Chelsea are unable to include former Newcastle striker Demba Ba, who joined Rafa Benitez's team during the transfer window from their Europa League rivals, for their clash with Sparta Prague.
But they have called up Yossi Benayoun and Nathan Ake, who captained Holland to last year's European under-17 Championship.
Elsewhere Brazilian Willian has been added to the Anzhi Makhachkala squad following his arrival from Shakhtar Donetsk for a reported £30million.