Bruce takes an injury-ravaged squad to the capital, and he admits that he looks at Spurs counterpart Andre Villas Boas' squad with some jealousy.
Danny Graham, Sone Aluko, Allan McGregor and potentially Robbie Brady will all miss the White Hart Lane match.
Villas-Boas spent much of the 100million euros Spurs received for selling Gareth Bale to Real Madrid on a raft of internationals, with Erik Lamela - signed for £30m - rarely getting game-time.
"They're certainly a challenger," said Bruce. "Spurs are now one of the big teams in the division as far as I'm concerned.
"Whether they are good enough to win it, that's a big call for them because they've got to beat Chelsea, Manchester City, Manchester United, Arsenal...but they've got a chance. In my opinion, they must have.
"The money they've been able to get in for Gareth Bale has bought five or six top, top players - the likes of Roberto Soldado, Christian Eriksen, Paulinho - it's endless. Then there's Lamela, that's £30m worth that we haven't really seen yet, it's a really strong squad of players.
"You can only applaud what they've done. They lost Gareth Bale, a wonderful footballer, but as a squad and as a team there's an argument they're even better.
"They've got better players than us, let's be honest. They've assembled a really good squad over the years but that's not to say we can't go there and get a result."