Speculation has emerged that the England striker is a top target for new QPR boss Harry Redknapp when the transfer window re-opens on New Year's Day.
But Defoe, Spurs' leading scorer this season with 10 goals in all competitions, claims he has no intention of linking up with Redknapp for the fourth time in his career.
"That's not going to happen. I'm not leaving Tottenham, I love the club and to score goals at a big club like this is fantastic," Defoe told Sky Sports News.
"If the opportunity comes to leave the club it won't be happening. I don't want to leave, I'm a Spurs player - and I'm happy. I'd like to finish my career at Tottenham. I want to achieve something special here - it's a great time to be at the club."
Spurs moved to fifth in the Premier League after Wednesday's 2-1 win over Liverpool, and Defoe is confident they can sustain their challenge for a Champions League place.
"I thought the performance against Liverpool was great. It was a massive win," he added. "Character is key and the lads who've come in have been fantastic. With the quality we've got it's important to go on a run and we're capable of doing that."
Defoe also offered his full backing to Spurs boss Andre Villas-Boas, who has struggled to win over the fans since succeeding Redknapp in the summer.
"It's difficult for any manager - when you come in you've got different ideas," said Defoe. "It wasn't the best at Chelsea but that happens. It's part of life and being a manager, but he's a fantastic manager and been fantastic for me.
"There's always a different approach each game and he's such a nice guy. All the lads want to fight and win for him. I'm just enjoying the journey and I'm sure he is as well."