The west London club dropped into the competition in December when they finished third in their Champions League group behind Juventus and Shakhtar Donetsk.
But Luiz insists the Chelsea players have put that disappointment behind them and are looking for success in Europe for the second year running.
Chelsea have to overcome Steaua Bucharest to progress to the last eight, starting with Thursday's first-leg in Romania.
Luiz said: "This is a great opportunity to win another European title. Last season it was in the Champions League, everybody was happy.
"I have the hunger again and I think Chelsea have the hunger again to win titles.
"This is one big club. This is the way you need to think to play for a big club.
"It's an opportunity to win one more game, the first leg and we're looking for the title of the Europa League."