France go into the game two points ahead of Spain with the opportunity to extend their lead at the Stade de France following their opponents' disappointing 1-1 draw with Finland on Friday.
France had no such problems with a 3-1 win over Georgia and Tottenham goalkeeper Lloris does not feel Les Bleus should change their approach against the side who beat them 2-0 at Euro 2012.
He said: "It doesn't change the way we'll be going into the game.
"We know how good Spain are and they are able to come here to win."
France face Spain following a win inspired by goals by Olivier Giroud, Mathieu Valbuena and Franck Ribery at home to third place Georgia.
Another win for France on Tuesday would leave Spain facing a potential play-off to reach the World Cup finals in Brazil.