The Magpies are due to face Benfica in the first leg of their quarter-final clash on Thursday in a competition that has brought some solace to the Newcastle faithful in light of their disappointing domestic campaign.
But Saturday's 4-0 defeat to Manchester City has left Pardew's side precariously close to the relegation zone and he admits the Premier League must be their priority.
"We have done well in the Europa League, but it can't detract from the Premier League," he said. "We have to make sure we are safe.
"We need two victories at least, and maybe a third or a fourth to get ourselves into a strong position."
The drain on his players is clear for all to see, with Cheick Tiote and Davide Santon amongst the players to miss out through injury against City.
"The Europa League is going to put us under pressure, because we are missing some big players at the moment," said Pardew.
"But we didn't do ourselves any favours against City because we were not aggressive enough."