McDermott's men have picked up four points in their last two games, in which the starting XI has been the same.
And despite a hectic schedule over the festive period, McDermott says he is not worried about fatigue.
"We are used to playing so many games from the Championship so it isn't really relevant to me. They love playing so we are getting results and sticking with the team, that is how I do it," he said.
"At the moment we want to pick up points, that's what makes people happy around here."
Spurs have lost just one of their last eight and although in-form Gareth Bale will miss the match through suspension, McDermott is not expecting an easier game.
"Gareth Bale is a top, top player, but they are not a one-man team, they have got players all over the shop now, terrific players," he said.
"I really like the manager (Andre Villas-Boas), he is a friend of mine. They have got one of our old players in Gylfi Sigurdsson, who we had here since he was 14, a top lad and a top player so we know what we are coming up against."
Spurs won 3-1 at the Madejski Stadium back in September but McDermott says his team are now acclimatised to the league.
"I obviously didn't learn too much because that was earlier in the season but we are learning now," he said.
"They played well that day and we didn't really compete the way we need to compete, but that was a long time ago and we need to make sure we go to White Hart Lane, get it right and see what the outcome will be."