Spurs haven't won at Stamford Bridge since 1990 but need to break that streak in order to clinch qualification for next season's Champions League.
Having broken a 23-year duck this season by beating Manchester United at Old Trafford, Villas-Boas is confident they can also win at his former club.
"We tried our luck at Old Trafford, it worked. We managed to change the history and the pattern. We will try the same way (against Chelsea)," he said.
"The knowledge that I have, I will try to pass it onto my players to see if in any way it can help in the decision-making."
Villas-Boas added: "We have had an excellent season. We beat all the big teams in the country, apart from Chelsea.
"We have an opportunity to go there and put our destiny in our hands, so we have motivation factors that go along with a fixture like this, we have the players' ability that is absolutely outstanding."
Harry Redknapp was axed as Spurs boss last season after they missed out on Champions League football and Villas-Boas is all too aware of the level of expectation within the White Hart Lane boardroom.
"The club is ready, but getting into it is the most difficult thing," he said.
"The resources that UEFA makes available in the Champions League are not available in the Europa League and I don't have to speak about the amount of notoriety you get from playing in the Champions League.
"It is the ultimate objective for any club going forward."