Rooney is only the fourth United player in history to reach the milestone after Sir Bobby Charlton (249 goals), Denis Law (237) and Jack Rowley (211).
At just 27-years-old, Rooney looks on target to become the club's all-time leading goalscorer and with 200 goals in 406 appearances, he averages a goal almost every other game.
After the game at Old Trafford, manager David Moyes said: "To surpass Sir Bobby would really be something".
Which one is your favourite?
Manchester United v Fenerbahce - September 2004
In what can be classed as one of the greatest scoring debuts in football history, Rooney tucked away a hat-trick in his first game for the Red Devils during their 6-2 thrashing of Fenerbahce in the Champions League.
Manchester United v Newcastle - April 2005
United were 1-0 down when Rooney spotted a poor clearance from the Magpies' Peter Ramage and charged forward to unleash a powerful volley that goalkeeper Shay Given had no chance of stopping.
Manchester United v Arsenal - April 2006
The striker has a good record against the Gunners so picking the best goal is a tough choice. We've gone for his 2006 goal at Old Trafford. A magic bit of skill to bring the ball down was followed up with a pin-point finish.
Manchester United v Manchester City - February 2011
An iconic goal against the club's fiercest rivals, Rooney's overhead kick winner against City was voted the best goal in the Premier League's 20-year history .
West Ham v Manchester United - April 2011
He made the headlines for swearing at a camera during the game, but a brilliant curling free-kick was the real talking point and part of a fantastic hat-trick against the Hammers.
Rooney has scored some incredible goals in his Manchester United career. Here at Sky Sports we have selected a few of those which you can see in the video above. Let us know your choice by leaving your comment below or voting in our poll.