The Ukrainian giants host the English champions at the Donbass Arena on Wednesday evening.
Both teams secured victory in their opening games and three points for either side in Donetsk would put that team in charge of Group A.
"We have the opportunity to win this game," Eduardo told The Sun.
"United may be in trouble but they are still strong and we have to concentrate.
"But they will be under pressure even if the teams have a different mentality in the Champions League and raise their game.
"We beat Arsenal here a few years ago and Chelsea last season. We always play very well at home."