The pair have scored 15 Premier League goals between them so far this season, with their form providing a rare bright spot in a miserable start to the season for David Moyes' under-fire side.
And Van Persie feels the understanding between the pair will be vital to their success and also that of the team.
"It's the interaction together, it's that we both want to play together," he said in an interview broadcast on MUTV. "We realise that we are better off playing together because we are stronger as a partnership.
"With a player of Wayne's calibre we can go from strength to strength and become even better than we are now.
"Lately we've been playing really well together, we've been setting up goals for each other, we are both scoring, which is what I want.
"It is important that this partnership is growing and becoming even stronger."
Van Persie feels the strength of both players' all-round games is what makes
them so difficult to play against.
"We are both 'nine-and-a-halves', we can play high up front, we can drop, it is an extra quality we both have which is quite rare.
"If you look around you have loads of main strikers, target men, 'foxes in the boxes', and you have 'number 10s' who are dropping in more and it's very obvious.
"With us it's not obvious, we can both do that job.
"Wayne is doing it a bit more because he's playing behind me but we can both do it so we can change the game if it's needed."