With the Red Devils having slipped 11 points off the pace in the defence of their Premier League title, cup competitions would appear to offer them the best chance of securing major silverware.
The towel will not be thrown in on the top flight crown, and United remain in the UEFA Champions League and Capital One Cup, but their 10-year wait for FA Cup glory is set to continue.
Moyes made sweeping changes to his starting XI for a meeting with Swansea - with seven senior players, including Wayne Rooney and Robin van Persie, out injured - but he claims the need to rotate had no bearing on the end result.
The Scot said: "No (not an excuse to have seven players out).
"We have another big game in 48 hours' time (against Sunderland in the League Cup semi-finals) so we had to keep that in mind but there are no excuses.
"We had a very strong team out. Just about every player on the pitch was an international."
United fell behind early to a well-taken Wayne Routledge chip, but responded positively to draw level through Javier Hernandez.
The tide turned against them, though, 10 minutes from time when Fabio - on the field for less than four minutes after replacing the injured Rio Ferdinand - was shown a straight red card and Wilfried Bony popped up to snatch a late winner for the Swans.
On the pivotal dismissal, Moyes said: "It was a sending off.
"It changed the game because we had the most control of it. Without getting the second goal I felt relatively comfortable.
"We don't come away thinking we deserved to lose - but we did."
Moyes concedes that confidence is starting to become an issue for his United troops, but has full faith in his players to turn things around.
He said: "You can definitely see we are lacking that little bit of confidence when we get into the final third at times.
"We need to get back to winning ways and be hard to play against. Most importantly, we need to take something out of the good play we have had in games.
"It has been a tough start. I am disappointed we have not won more games but it will change I have no doubt about that.
"It shouldn't be that (United are reliant on likes of Rooney and Van Persie).
"My job is to find a way of winning. It doesn't matter what style you have to find a way of winning."
While finding himself in a tough spot at present, Moyes says he has no intention of panic-buying in January in an effort to try and find a quick fix.
On possible additions, he added: "I have said I will try to get players but it will probably be doubtful in January. I have said that quite consistently.
"There is an urgency that we would like to bring players in but are those players available in January?
"There is no point in me hyping it up and saying we are because players we would like to bring in are probably not available."
Swansea are back at Manchester United on Saturday when the two go head to head in the Premier League. The game is live on Saturday Night Football, Sky Sports 1HD and Sky Sports 3D from 5pm.