Rafael Benitez's side take on the Portuguese outfit at the Amsterdam ArenA 12 months on from their dramatic penalty shoot-out success against Bayern Munich in the Champions League final.
Victory would mean the club would become the first side to win the Champions League and then Europa League in successive seasons and they would briefly hold both titles ahead of the Champions League final at Wembley next week.
It would also ensure the club end a long campaign with silverware after falling at the semi-final stage in both domestic cup competitions, losing the World Club and Super Cup finals and failing to keep up with the two Manchester sides in the title race.
Mata, who has played 62 games for the Londoners in all competitions this season, believes it would be a fine achievement for Chelsea if they win in Holland on Wednesday.
"We have now the chance to win two European trophies in a row, which is not easy for any club and we will try to do it," said the Spain international.
"It would be very, very nice. After winning the Champions League and FA Cup [last season], it would be really nice and I would be really pleased to win another trophy with Chelsea.
"It's been a long season in terms of the amount of games, but I think it's good. I'm really happy with the season personally, but it's not finished yet. It can be even better, if we win the title."
Mata has also praised boss Benitez for his efforts since taking over in November, with the former Liverpool manager widely expected to leave at the end of the season.
"The manager's trying to rotate the players, we're resting," he added. "It's been a pleasure for me. He's a top manager, he's tried his best. If we win the trophy it will be great for him and the team."