Both sides rang the changes for Tuesday night's game at the Emirates Stadium, with Arsene Wenger making eight changes to the team that won at Crystal Palace on Saturday.
However, they were comfortably beaten by a Chelsea side that featured 10 changes - Gary Cahill was the only survivor from Sunday's win over Manchester City - and yet still featured international stars such as Juan Mata, Samuel Eto'o and Michael Essien.
Sky Sports expert Wilkins says the 2-0 scoreline demonstrated the difference in squad depth between the two clubs and feels that could be of concern to Wenger.
"We've basically seen a Chelsea reserve team come out tonight and wipe the floor with Arsenal," he said.
"Arsenal haven't shown anything whatsoever against this Chelsea team. Chelsea have been so superior to Arsenal tonight that it's almost been slightly embarrassing in the way Chelsea have won this evening.
"Jose hasn't learned too much. He knows he has a fantastic squad of players and that was pretty evident tonight when you see that Chelsea can put this team out and yet there will probably be eight changes at the weekend.
"This is a squad of fantastic footballers like Michael Essien who hadn't taken part this year and all of a sudden he comes in at the Emirates and he's outstanding.
"They have a wonderful squad of players and whichever team they pick, they win."
Cesar Azpilicueta opened the scoring in the first half and Spain midfielder Mata, who was given the Man of the Match award by the Sky Sports pundits, scored a fine second for Chelsea.
The club's Player of the Year has struggled to hold down a first-team place following the return of Jose Mourinho with the Chelsea boss apparently preferring the work-rate of the Oscar and Ramires.
But Wilkins cannot understand why Mata doesn't start more often and says questions should not be asked of his attitude.
"He's a fantastic footballer, I've got to say," he added.
"Jose has a massive problem in who he selects, but this guy is a genius of a footballer. He's a wonderfully gifted young man.
"I haven't [seen any change this season]. I've always thought the guy was a different class.
"I think he's giving more of that this year and I really think he's always worked extremely hard. I don't honestly understand what Jose was trying to get more out of him.
"I think this young man is something very special. When you hear him speak he speaks with a lot of humility and he's very humble in the way he speaks.
"He's a proper bloke, but he's a wonderfully gifted player and I don't know what more Jose was trying to get out of him."