The Premier League club drew Drogba's Galatasaray, who are managed by former Manchester City boss Roberto Mancini, in the first knockout stage of the Champions League.
The Ivorian spent eight years at Chelsea and scored the winning penalty in the shoot-out when the Blues beat Bayern Munich to win the Champions League in 2012.
Mikel told the club's official website: "We shouldn't get carried away about him coming back; he is a player that was here for eight years, he won major trophies, he's a big player with a big personality.
"Obviously he had to move on but Chelsea continue, we have to win games, he's coming here with his new club, Galatasaray, who we want to beat, so we shouldn't get carried away about him coming back, we want to win the game.
"It will be tough but it's a game we're looking forward to. It will be good to meet old rivals, who you have played against in the past, as well as old team-mates."