Chelsea's 3-1 victory over the reigning champions kept Jose Mourinho's side just two points adrift of leaders Arsenal in third place in the table.
Brazilian midfielder Ramires has yet to win the title since joining Chelsea from Benfica in 2010 and he is determined to end the season on top.
"I love to be on the pitch in big games like the one against Manchester United," the 26-year-old told Globo Esporte.
"The derbies make you feel butterflies in your stomach, make you more motivated to win and I am happy that we have managed to play well.
"We are now even more confident after that game that we can reach our goal of winning the Premier League, that would be even more special to me as I have never won that title."
The success over United was Mourinho's 100th as a Premier League manager and was also a significant milestone for Ramires.
The win racked up a century of victories for Ramires since his move to Stamford Bridge and he is delighted with how his career has progressed over the past four years.
He added: "Thank God my career has been improving since I joined Chelsea, many good things have been happening and I have got recognition for my work, which makes me very happy.
"I find the fact that I achieved that milestone as a consequence of the joy I have of playing football and of wearing Chelsea's shirt."