UEFA's control, ethics and disciplinary board ordered PSG to close two sections – 104 and 105 – of the Parc des Princes at their next home match in the Champions League group stage.
The incident occurred during the Champions League quarter-final first leg on April 2 which was won 3-1 by the French champions, with Chelsea winning the return leg 2-0 to advance.
"The sanction has been imposed for the discriminatory conduct of some Paris St Germain supporters towards disabled fans of Chelsea FC (Art. 14 of the 2014 UEFA Disciplinary Regulations)," UEFA said in a statement.
As French champions, PSG have qualified directly for the group stage this season and the ban will apply at their first home game.