The European law enforcement agency said one Champions League match played in England is under investigation.
According to Danish newspaper Ekstra Bladet, Europol is looking at Hungarian side Debrecen who lost 1-0 to Liverpool at Anfield in 2009.
There is no suggestion that anyone at Liverpool was involved in any wrongdoing.
Vukasin Poleksic, the Debrecen goalkeeper that night, was banned for two years in 2010 by UEFA for failing to report match-fixing activities involving a different game.
A Liverpool spokesman said on Tuesday: "We have had no contact from Europol or any other organisation over this."
Europol has not revealed which Champions League match in England is under investigation but that it took place "in the last three to four years" and is one of 380 games being studied.