The strike duo have scored seven times in six appearances together this season but their partnership has been put on hold of late because of Sturridge's ineligibility in the Europa League and a thigh injury.
However, the England international returned to training this week and is on course to team up once again with Suarez, whose hat-trick against Wigan last weekend made him the Premier League's top-scorer with 21 goals.
"We can't keep relying on Luis for goals and you need someone else to chip in," said Downing.
"I think Daniel has been a good signing for us and although we missed him against Wigan, in the games he has played he gives us something different.
"The way they play, he (Sturridge) is on the (centre-back's) shoulder with Luis coming off, they are a nightmare for defenders. If we can get a good partnership with them going then we have a chance."
Liverpool are currently 10 points behind fourth-placed Chelsea but this weekend's visit of Tottenham represents the Reds' only encounter against a team in the top half of the table until they host the Blues on 21 April.
Downing is focused primarily on the game against Tottenham, a team he feels Liverpool were unlucky to lose 2-1 to in November last year.
"If we can beat them we'll keep chopping away at them," he added. "There's no point saying we want to finish fifth or sixth. We've just got to try and win our games and see what happens.
"It's going to be a great game. They've got good offensive players and the way we're playing at the minute, we can get goals.
"They will know they are in for a tough game. We played them off the park at White Hart Lane. I know we lost but if you look at the game I don't know how we lost - a great game to play in.
"The way we're playing and the way they're playing, it's set up for a good game. I'm confident we can get a win."
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