The game at Stamford Bridge comes just three days after the Reds' trip to Manchester City for a game which saw them beaten 2-1 and, as a result, relinquish their place at the top of the Premier League table.
This weekend, they come up against a Chelsea side who are unbeaten at home in the league this season and are a point and place above them in the table.
"For us it couldn't be any tougher," admitted Rodgers. "We're playing against the two teams who arguably have the two best squads in the league.
"They can change all 11 players and still have a team that challenges at the top of the table.
"We'll go into the game and do our best, that's what we have done.
"Of course this period is always difficult, no matter what way you look at it.
"It's not ideal but it's what happens and it's what makes it exciting to be in the country at this time. We embrace it and we'll look to get a result."
Liverpool will again be without the injured Steven Gerrard, Daniel Sturridge, Jose Enrique and Jon Flanagan, while Victor Moses is ineligible to play against his parent club.
But Rodgers was pleased with the way side played against City and is backing his players to produce another good display at Stamford Bridge.
"The last game gives us confidence and belief, but we arrive into this game knowing it's going to be equally difficult," added Rodgers.
"Over my time here, whatever squad we are working with, we have always been able to galvanise the group. The team has been able to go again and that's something that we'll look to do for the weekend.
"We've been improving as the season has gone on. If you look at the last number of weeks, the performance level and the standard has been at a real high level.
"I think we're a team that shows great confidence and belief in how we're training and how we're working.
"We're taking that confidence into any stadium, home or away, and that's always difficult for an opponent.
"I think you've seen the aggression, the charisma, the confidence and the consistency over these last 12 months."