The Gunners are winless in 2013, with Sunday's 2-0 home defeat to Manchester City leaving them sixth in the Premier league table.
With an FA Cup third-round replay against Swansea on Wednesday and a UEFA Champions League first knockout round tie against Bayern Munich on the horizon along with a number of important league games, Vermaelen is keen to get back to winning ways.
"There are a lot of big, big fixtures coming up against good teams - big games," he told Arsenal Player.
"This (the defeat to City) was the first one, we wanted to have a good start and that is why it is more disappointing we could not get a good result.
"But against Swansea, I am confident the group will respond on this defeat, and I'm confident we can get a result on Wednesday."
Arsenal's next Premier League game is away at Chelsea on Sunday, which is followed by the rearranged Boxing Day clash with West Ham at the Emirates before another home game against Liverpool.