As ever, we'll bring you all the goals as they go in across the country, but before the action gets underway we'll take a closer look at six of the teams hoping to grab the headlines by knocking out Premier League opposition.
Tune in to get the inside line on Brentford's clash with neighbours Chelsea, Brighton's game with Arsenal, Oldham's meeting with Liverpool, Bolton's clash with Everton, Macclesfield's match-up with Wigan and Sheffield United's trip to Reading.
We'll also be hearing from giant-killing mastermind Phil Parkinson, who has inspired his Bradford side to Capital One Cup victories over Wigan, Arsenal and Aston Villa this season in a magical run which will see the Bantams face Swansea in the League Cup final at Wembley in February.
The Welsh club's progress to that final - their first major domestic final - was somewhat overshadowed by Eden Hazard's clash with a ballboy late on in the game.
We'll get our pundits verdicts on the incident and they'll also share their views on Chelsea's below-par performances in both legs of that semi-final, as well as their take Villa's struggles under Paul Lambert this term.
Then, at 3pm, the football gets underway and Soccer Saturday is the only place to be to keep track of all the goals as they fly in up and down the land.
Don't miss Soccer Saturday, 12pm, Sky Sports News HD.