Akpan is thought to be undergoing a medical at the Madejski Stadium after Crawley accepted a bid from Reading for the midfield dynamo.
The 21-year-old has impressed at Crawley since arriving on a free transfer in the summer of 2011 and his performances have attracted interest from clubs higher up the football pyramid.
A number of Championship clubs were thought to be lining up moves for Akpan in this month's transfer window, but Reading have moved in to offer him a chance to play in the Premier League.
The all-action midfielder impressed Reading's coaching staff during last weekend's FA Cup clash between the two sides and they have moved quickly to try and land the player.
Akpan is expected to sign a three-and-a-half-year deal at Reading and will become the club's second signing of this month following the arrival of Daniel Carrico from Sporting Lisbon.