The loss left the Royals seven points adrift of safety in the Premier League with only six games remaining, but Le Fondre remains optimistic.
"We've got to start expressing ourselves on the ball a bit more," he said.
"And we'll pick ourselves up and go again. It's not in our make-up to give in.
"Never say never and until it's mathematically impossible, we still believe.
"We'll always battle to the end - that's what the fans expect from us and it's what we expect from ourselves.
"We're paid professionals and we'll give our all for the cause.
"We've got Liverpool here next weekend and we love games like that, so we'll welcome the challenge and try to make it horrible for them."