The Royals will be aiming to preserve their unbeaten home record in the Championship this season against a Rangers side who have only lost once on their travels.
Pearce said: "The mood's been good, we got over the defeat quite quickly.
"Early on in the week we looked at the goals, we saw where we could have done better and we were all open and honest with what we were saying with each other.
"We know that we're better than that, to concede five goals in any game is not good enough and we know that as a group of players, we'll be looking to put that right.
"We'd like to think that the Madejski is a bit of a fortress for us at the moment and we'd like to just keep that going.
"We know what QPR are about, we know they're a good team, they'll be looking to get a positive result and so will we."
Pearce was linked with a summer move to Liverpool but signed a new contract with Reading and is just happy to focus on his football for the time being.
He said: "I'm very happy. I signed a two-year contract in the summer and I was pleased to get that signed and sealed. It went on for a bit but you know I'm pleased to get it done now and crack on with the season ahead.
"I'm just focusing on the club that I'm at right now and I'm really pleased to be here. Hopefully we can get this club back into the Premier League."
Watch QPR take on Reading live on Sky Sports 1 HD on Saturday, kick-off 12.15pm.