Caulker, who scored his first Spurs goal in the 2-1 defeat to Manchester City before scoring on his England debut against Sweden on Wednesday, was part of an experimental side that lost 4-1 to Arsenal in the League Cup two years ago.
The centre-half gained a measure of revenge when he triumphed over Arsenal while on loan at Swansea last season, but he cannot wait to be part of a Premier League north London derby.
"It will be very surreal knowing that in the space of two years I will be playing them again in a Tottenham shirt in a league game," he told Spurs TV Online.
"That's what I have always wanted to do. Last year I beat Arsenal 3-2 when I was at Swansea. That was obviously a great moment and I hope we can do the same at the weekend."
"Going on loan has been crucial for me, especially the season at Swansea. We played in such a way that it improved my composure on the ball and it helped me learn how to play it out from the back."