The 23-year-old suffered an ankle injury in Tottenham's game against Fulham on Sunday and has not yet trained this week, but team-mate Sam Vokes believes he will be in the starting XI for the Sky Live clash on Friday night.
He said: "We think he is going to be fit, he is in and around the team and will be training in the next couple of days with Friday in mind.
"It is fantastic to play alongside him, the last couple of goals I have scored for Wales have come from his assists, and in the Scotland game here he turned the game on its head.
"He has been different class for club and country for a while now, every game he plays in he is excellent and he will be a big player for us on Friday."
Vokes found the net in the 2-1 win over Austria last time out, becoming the first player other than Bale to score for Wales under Coleman.
"Hopefully Friday is a big chance for me," Vokes added. "Although Craig Bellamy started there against Austria so it depends which way the manager wants to go, but I want to put my name forward."