Spurs go into the game unbeaten in five matches and on the back of a 4-1 thumping of Anzhi Makhachkala 4-1 in the Europa League.
They will face one of their trickiest hurdles of the season this weekend when Suarez comes to White Hart Lane having scored 15 goals in his last 11 matches.
And Villas-Boas admits that they will have to be at the top of their game to stop the Uruguay international.
"He's a player going through a wonderful individual moment," the Spurs boss said.
"He's full of the confidence. We have to be aware of his strengths. He's a player that individually can solve the game.
"So we have to be aware not only of the people that feed him but the actual individual moments of brilliance that we saw this season, that have been so decisive for Liverpool.
"He's a key player for them and very difficult to stop."
Villas-Boas' position came under scrutiny a few weeks ago after their 6-0 hammering at Manchester City. But a good run domestically and in Europe has eased the pressure.
"We have had a good recovery and a good response from the team from that setback," Villas-Boas said.
"If we manage to get a win against Liverpool we're completely back on track with the top teams.
"It's a big, big game for us - we won't be that far off, even if we don't win that game."