Central defender Vertonghen has played at full-back since Benoit Assou-Ekotto suffered a knee injury in September.
With Assou-Ekotto nearing full fitness, Vertonghen hopes to move back to his favoured position in the middle of defence.
When asked whether he found it frustrating playing at full-back, the 25-year-old said: "Yes, and the manager knows.
"I prefer centre-back but I want to help the team.
"It would be good to have Benoit back but not only for that reason as he is one of the best left-backs in the league."
Due to his time at left-back, Vertonghen is likely to be denied the chance to mark compatriot Christian Benteke as Spurs face Aston Villa on Boxing Day.
Benteke has taken the Premier League by storm since moving to England, but Vertonghen says he is not surprised by the impact he has made.
"It doesn't surprise me that he has done well," Vertonghen said.
"He now feels the confidence of the team, the crowd and the manager.
"You could see that in the last two games for the national team (when Benteke scored in wins over Serbia and Scotland). He was very good then and I think that Aston Villa made the right choice to sign him.
"He is very good in the air and he can score. He will be a very tough player to play against."