All three sides are currently languishing in the Premier League relegation zone and Lowton admits it is vital for Villa to pick up some important points in the next fortnight.
The defender was encouraged by a spirited display in losing 1-0 to Manchester City on Monday and is confident of beating the drop.
"We said before the Man City game that we had to compete. It's encouraging that we did that," he told the club's official website.
"We didn't create enough chances to maybe earn a point. But the effort and endeavour was definitely there.
"We have to make sure it is between now and the end of the season.
"It would have been great to get the three points against Man City. But the next two matches are vitally important for us.
"We have to take the confidence from the performance and the endeavour into Saturday."
Lowton added: "The next two Saturdays are massive games for us. We have to show the fight that we have done and the quality will come through to get the points we need.
"Overall it gives us confidence knowing that if we can keep Man City to a few chances, hopefully we can do the same against Reading and QPR."