The defender has reportedly attracted the attention of Premier League clubs Liverpool, Arsenal and Newcastle United and admitted earlier this week that he was desperate to play more regularly, having had to battle with Thiago Silva and Alex for a starting spot this season.
However, Makelele has ruled out the possibility of the 23-year-old being sold and has challenged him to prove he should be first choice at PSG.
"Mamadou is the future of the club," former Chelsea midfielder Makelele told Le Parisien.
"It is impossible he could leave. Sometimes I also had bad thoughts as a player. He has to reject them.
"Of course he needs to hear that he is important, but sometimes he has to remain quiet. Mamadou has now reached a level where he cannot act as a child and ask for affection. He is a professional.
"He is in a world where the strongest ones don't say anything. The more Mamadou shows his power on the pitch, the more it will be impossible to not play him. Because he is just a great defender."