Pardew blamed fatigue for his side's 3-0 derby defeat at home to Sunderland and claimed the club's run to the Europa League quarter-finals had taken its toll - especially on his playmaker.
Pardew said: "Cabaye is probably my biggest worry. The rest of them are really sound physically and mentally.
"But Cabaye is our best player in terms of intelligence on the pitch and he needs to play. That's why he has played almost every minute."
Newcastle, who sit five points above the drop zone, travel to West Brom on Saturday looking to end a run of four straight Premier League defeats on the road.