The Shrimps are expecting to welcome a record crowd - as well as the Sky Sports cameras - to the Globe Arena.
And with Newcastle having well-documented difficulties on and off the pitch, Amond says an upset is not out of the question.
United, yet to score a goal this season, travel without their midfield playmaker Yohan Cabaye - still the subject of speculation about a move to Arsenal - injured striker Loic Remy and suspended defender Steven Taylor.
They were hammered 4-0 by Manchester City in their season opener, and were held to a 0-0 draw by West Ham at home on Saturday.
Amond said: "I actually watched the game the other night against Man City and obviously Steven Taylor got sent off so it looks like he could be missing and they've picked up a couple of little injuries.
"They're obviously a really, really good team with Premier League experience for a number of years now so it's going to be a very tough game, but there's no pressure on us, all the pressure's on them, they're expected to beat us.
"There's no-one really that we're scared of or anything like that. We're just all really looking forward to the game."
And Amond says they are playing Newcastle at an ideal time: "We'd like to take advantage of it. A couple of things have gone our way with the Cabaye interest (from Arsenal) and things like that and you don't know who's going to play, but whatever team Newcastle is going to put out is going to be an extremely good team.
"It would be silly if we said they're understrength and took them lightly. We're not going to do that because they're a Premier League team at the end of it all.
"Every player has Premier League and European experience so it would be quite silly just to dismiss it because there's quite a few players injured, but it's just a game we're really, really looking forward to.
"Playing in front of a big crowd and playing live on Sky again should inspire the lads and, you never know, it could be a great day for Morecambe."
"You never know what's going to happen. If you'd have said this time last year Bradford City would be in the cup final, a lot of people probably would have laughed at you.
"But as it turned out they had a great cup run, and they were able to bring it into their league form at the end of the season."
You can watch Morecambe v Newcastle live on Sky Sports 4HD at 7.30pm