The most eye-catching fixture sees Arsenal pitted against London rivals Chelsea following their tense penalty shoot-out win over West Brom.
Manchester United face Norwich City at home while neighbours Manchester City will visit Newcastle United.
Tottenham will face Premier League new-boys Hull and Sunderland will take on Southampton at the Stadium of Light.
The other fixtures see Fulham visit Leicester, Stoke visit Birmingham City and West Ham visit Burnley.
Capital One Cup fourth-round draw in full:
Sunderland v Southampton
Leicester City v Fulham
Birmingham City v Stoke City
Manchester United v Norwich City
Burnley v West Ham United
Arsenal v Chelsea
Tottenham v Hull City
Newcastle United v Manchester City
Ties to be played on October 29 and 30