The two teams will meet again in the FA Cup final next month but Martinez's side are focused on securing points as they continue their battle for Premier League survival.
Wigan have lost their last six meetings with City, failing to even score in the process, leaving Martinez the challenge of changing his personnel without significantly weakening a side that has seen just one change in the last five matches.
"I think it is more difficult because you need to make sure those players are fresh enough to keep playing and I think it is important to make sure we don't overload certain players," he said.
"What is important as well is to give a sense of continuity but I know we could make three changes and that wouldn't affect our performance and that is a very important feeling to have as a manager.
"When you can make changes from one game to another and not have a problem from a tactical point of view, it shows the work which has been put in over the last 10 months or so."
Martinez also praised the sense of unity within the camp, insisting the good of the group always comes above the needs of the individual.
"Players are desperate to help the team. There are no individual cases, from now until the end of the season it is about what we can do as a football club," he added.
"There is a bigger role than playing or not playing. Everyone is aware the achievement as a team is more important than individuals.
"We have players who are fully aware of what they need to bring to the team and everyone is expecting to be used from now until the end of the season.
"If you have a player who is happy not to play he needs to move on, he's in the wrong business.
"Every player should be desperate to play and be disappointed for one second but after that there is a real sense of the group and what the team needs.
"People are very committed, they are desperate to help the team, but when they are on or off the pitch they know how to behave themselves.
"I think that is what we have showed in the last few weeks - a big club mentality in terms of facing every single game and forgetting about the individuals."