For Roberto Mancini's side, it is a second final in three years after the beat Stoke 1-0 to lift the famous trophy in 2010 - their first piece of major silverware in 35 years.
The Latics, though, are making a first appearance in the final in their 81-year history and only their second in a major final after they were beaten 4-0 by Manchester United in the 2006 League Cup.
Here is how the two teams reached the final:
Third round v Watford (H) 3-0
Mario Balotelli's training ground bust-up with Roberto Mancini dominated the pre-match headlines but there was no drama on the pitch as City made light work of their Championship opponents. Carlos Tevez struck a superb free-kick and Gareth Barry and youngster Marcos Lopes were also on target in a routine win.
Fourth round v Stoke (A) 1-0
City didn't have quite so easy in round four against fellow Premier League side Stoke. A tight game was settled five minutes from time when Pablo Zabaleta struck the game's only goal.
Fifth round v Leeds (H) 4-0
Coming off the back of a damaging Premier League defeat to Southampton, City bounced back in the fifth round to dispatch second-tier Leeds at the Etihad. Yaya Toure got the scoring under way, with Sergio Aguero grabbing a brace either side of a Tevez goal.
Quarter-finals v Barnsley (H) 5-0
Another Championship side, Barnsley, were swept aside even more ruthlessly in the last eight. Tevez continued his impressive scoring form in the competition with a hat-trick, while also setting up goals for Aleksandar Kolarov and David Silva
Semi-finals v Chelsea (Wembley) 2-1
For just over an hour, City were outstanding, building up a seemingly comfortable lead through Samir Nasri and an Aguero header. However, the closing stages required resilience after Demba Ba pulled one back for the London side. City survived, though, despite a strong Chelsea claim for a penalty.
Third round v Bournemouth (H) 1-1
Wigan were given a scare in the third round as League One Bournemouth took the lead at the DW Stadium through Eunan O'Kane and held it until the 70th minute. Fortunately for the Latics, Jordi Gomez was able to salvage a draw by scoring on the rebound from his own penalty.
Third Round replay v Bournemouth (A) 1-0
Argentinian striker Mauro Boselli scored the only goal of the game as Wigan made amends for the initial tie at Dean Court.
Fourth Round v Macclesfield (A) 1-0
Roberto Martinez's side got a tougher work out than they expected from Conference side Macclesfield but came through the challenge thanks to another Gomez goal from the spot.
Fifth Round v Huddersfield (A) 4-1
There was no problems in round five as the Latics ran riot at Huddersfield. Callum McManaman, Arouna Kone and James McArthur putthem 3-0 up inside an hour with Kone grabbing a late second after Lee Novak had pulled one back.
Quarter-final v Everton (A) 3-0
Wigan's most impressive win of their run to the final. Everton were favourites to advance but were blown away by a a 202-second spell during which the away side scored three times. Maynor Figueroa, McManaman and Gomez bagged the goals.
Semi-final v Millwall (Wembley) 2-0
An inspired performance from Shaun Maloney was rewarded with a goal midway through the first half and McManaman continued his fine form with the vital second 12 minutes from time to set up the showdown with Mancini's men.