After several years of legal wrangling, the London Legacy Development Corporation finally confirmed last week that it had chosen West Ham to become the main tenants of the London 2012 stadium in Stratford.
The Hammers are expected to move in to the 60,000-seater venue at the start of the 2016-17 season but, while the move has divided opinion among supporters, O'Brien is sure it will herald an exciting new era for the club.
"I think it can only mean good things for the club when you move into a stadium like that," O'Brien said.
"You can attract players and supporters from all over the world to play and watch there.
"If the club want to push on and to finish higher in the league, then we need a bigger stadium and to fill it to get the revenue into the football club. It's a great step forward.
"Looking at the stadium when the Olympics were on and seeing what the club want to do with it by turning it into a football stadium, it looks unbelievable."
Premier League survival is a more pressing focus and, though Sam Allardyce's side are six points above the drop zone, forthcoming fixtures against Manchester City, Liverpool and Manchester United mean Saturday's home match with West Brom is viewed as a chance to climb to further comfort.
"If we get the three points it would set us up for a nice end to the season," O'Brien added.
"We're in a decent position but if we can get a couple of wins in our next couple of games we'd be in a really good position."