The Hammers go to the Etihad unbeaten in their last five games and the defender says they want to maintain that run until the end of the season.
Victory at City will guarantee Premier League survival, although realistically Sam Allardyce's men should already have done enough to stay up.
Reid said: "We know City have quality players. They have the likes of Edin Dzeko, Sergio Aguero and Carlos Tevez, and it will my job and that of my team-mates to stop them.
"They have quality throughout the side, but we are five games unbeaten and keen to finish the season as strong as (we can).
"We have got ourselves in a good position so why wouldn't we want to keep that going and see where we can get to with the last four games?
"We are looking forward to the run-in, as we want to keep this going."
The reverse fixture back in November finished 0-0 though the East Londoners had a goal by Kevin Nolan incorrectly chalked off.
"We know that facing them on their own ground is going to be extra tough because as the former champions they will still want to finish the season well and grab that second place," said Reid.
"Even though they haven't got the title back they have an FA Cup final to go for and they will want to finish well.
"We were unlucky not to beat them back at Upton Park earlier in the season - our captain Kevin [Nolan] had a goal which was deemed offside and it ended up being a 0-0 draw."