Nolan scored the only goal of the game to give the Hammers a rare away victory when the teams met earlier in the campaign.
But ex-Hammers manager Alan Pardew will bring Newcastle to Upton Park with his team on a worrying slide, having picked up just four points from a possible 18 in recent weeks.
Defeat for the visitors could see them drop into the bottom three if Wigan win their game in hand, and McDonald insists there is no room for sentiment.
"I think Andy and Kevin are looking forward to the game," McDonald said.
"Andy being a young kid growing up there and Kevin having had a relegation and promotion in his time."
McDonald is also backing Carroll for a return to Roy Hodgson's England squad as the Liverpool loanee has rediscovered his scoring touch.
"I think they should," McDonald added. "He is in really good form and his contribution, his inter-link play is very good and that reflects in our recent results."