Sam Allardyce's men then travel north to play his former club Newcastle United before returning to London to play Stoke City at home on 31 August.
In September, Roberto Martinez brings his Everton team to Upton Park while a week later West Ham face Steve Bruce's Hull City at the KC Stadium.
Christmas is traditionally a busy time for players and fans and on Boxing Day West Ham have a London derby at home against Arsene Wenger's Arsenal.
The West Ham faithful won't have too far to travel on New Year's Day either when they face Fulham at Craven Cottage.
And West Ham will wrap up the season with a home game against Tottenham followed by an away trip to Manchester City on the final day.