Hughes limped off after half an hour of the Rams' goalless draw at Reading at the weekend.
First-team coach Paul Simpson insists Derby will not take any risks with the 18-year-old midfielder but he is optimistic about Hughes' chances of returning to training ahead of Saturday's clash at the iPro Stadium.
"Will has come in today (Monday) and he is feeling a lot more comfortable," Simpson told the media.
"The scan showed signs of a very small strain but we are hopeful that if we can look after him and wrap him in cotton wool for the first part of the week, he will be able to join in training by the end of the week and be available for the weekend.
"We will err on the side of caution because we want him available, and so if he has to miss one game and be available for the last nine games then that is better than playing on Saturday and not being available after that.
"Fingers crossed, he will come through the week and be available for selection against Forest."