David Vaughan and Connor Wickham both left the Stadium of Light for the Championship last week, joining Nottingham Forest and Sheffield Wednesday respectively until January.
However, with Ondrej Celustka and Emanuele Giaccherini sustaining knocks in Wednesday's Capital One Cup clash with Southampton, Poyet's resources are becoming depleted.
To add further to the Italian's woes, both Lee Cattermole and Adrea Dossena begin three-match bans this weekend after picking up red cards against Hull City last weekend.
"It's going to be more difficult to let anyone else go, for sure," Poyet told the Sunderland Echo.
"But we've got plenty of bodies and the international break is coming up, so we'll manage."
Wickham, who enjoyed a spell on loan at Hillsborough last term, began his second stay with the Owls successfully last weekend, netting as they registered their first victory of the season.
The striker, who was left out of the England Under-21 squad for the games against Finland and San Marino, has made just nine Premier League starts since his £8million move from Ipswich in 2011.
Poyet remains eager to see Wickham gain experience but believes the 17-cap Under-21 international is in a similar situation to Wilfried Zaha, who is yet to make his top-flight bow for Manchester United since his £15million switch from Crystal Palace.
"Connor needs games," Poyet added. "I think he's a player who when we saw him come in at Ipswich, when he was 17, he was impressive.
"The difficulty then is, at the end, he needs to play, wherever that is.
"I think perfection would be the new club continues paying (the wages), the old club gets the money and everything is right by the player and they're playing as much as possible.
"I think it's similar to Zaha at Man United. Look at what has happened to him this year, he's hardly played and they're talking about letting him go on loan."