The Albion head coach took advantage of his team's comfortable position by trying a new formation and giving run-outs to several fringe players in the 1-0 midweek defeat at Manchester City.
Boaz Myhill came in for Ben Foster in goal while Craig Dawson, Markus Rosenberg and Gabriel Tamas all started at the Etihad having rarely featured for much of the season.
Clarke may opt to do something similar against Norwich at Carrow Road, where victory for Albion will plunge their hosts further into the relegation mire.
"I put my best team out against Manchester City," he said. "It was the best team for that night. What I do with my team shouldn't be any concern for anyone else. I've got a squad of players that I use but I've used them all season.
"We know we've got a duty to the rest of the teams in the league to go out there and try our best. But I don't think anyone could ever accuse us of not doing that in any game this season.
"We've always tried our best and that's what we'll do this weekend. We've been able to look at Markus and Craig and Gabi Tamas came back into the team and did well.
"I've got a good squad and I think the fact we've not been out of the top half all season proves that. It was good to get one or two of them a game, it was good to try a different system which has been in my head for a number of weeks to try. You have to find the right game to try it and that was the one."